Treatment of Severe Skin and Soft Tissue Infections

A Review

Jason P. Burnham; Marin H. Kollef


Curr Opin Infect Dis. 2018;31(2):113-119. 

In This Article

Defining Severity in Soft Tissue Infections

Severity of illness due to SSTI loosely correlates with depth of skin structure involvement, though there is no universally agreed upon severity scoring system. For the purposes of this review, we will consider patients with toxic shock syndrome (TSS), necrotizing fasciitis, or gas gangrene/myonecrosis as having a severe SSTI. In addition, patients having any SSTI meeting criteria for severe sepsis or septic shock or having a quick Sequential Organ Failure Assessment score at least 2 will be considered to have a severe SSTI. Table 1 lists some of the common pathogens in severe SSTI, their features, and recommended antimicrobials.