Age and Fecal Microbial Strain-Specific Differences in Patients With Spondyloarthritis

Matthew L. Stoll; Pamela F. Weiss; Jennifer E. Weiss; Peter A. Nigrovic; Barbara S. Edelheit; S. Lou Bridges Jr; Maria I. Danila; Charles H. Spencer; Marilynn G. Punaro; Kenneth Schikler; Andreas Reiff; Ranjit Kumar; Randy Q. Cron; Casey D. Morrow; Elliot J. Lefkowitz


Arthritis Res Ther. 2018;20(14) 

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Our study supports previous work indicating that decreased fecal abundance of a regulatory strain of F. prausnitzii may be at least partly responsible for the pathogenesis of SpA, possibly due to decreased production of butyrate, and that efforts to replenish it in patients with SpA may be a potential therapeutic avenue. In contrast, to the extent that increased abundance of Bacteroides or B. fragilis in children reflects altered immunologic development rather than direct pathogenicity or the organism, enthusiasm for microbial-based interventions to address this organism may be tempered. Instead, our findings may underscore the necessity for prevention efforts, such as avoiding unnecessary use of antibiotics in healthy children.[54,55]