Diabetic Microvascular Disease: An Endocrine Society Scientific Statement

Eugene J. Barrett; Zhenqi Liu; Mogher Khamaisi; George L. King; Ronald Klein; Barbara E. K. Klein; Timothy M. Hughes; Suzanne Craft; Barry I. Freedman; Donald W. Bowden; Aaron I. Vinik; Carolina M. Casellini


J Clin Endocrinol Metab. 2017;102(12):4343-4410. 

In This Article


Increasingly we have learned that the microvasculature within different tissues serves multiple functions beyond being a conduit for exchange of respiratory gases, nutrients, and metabolic waste. Consequently, microvascular injury can express common and unique changes at different sites. The dynamic between microvascular injury and repair determines the manifestation of tissuespecific injury. Diabetes affects both injury and repair processes in a manner distinct from other vascular diseases. We have summarized both the general molecular processes involved in diabetic microvascular disease and many of their tissue-specific expressions. Clearly, there is much we still do not understand, and consequently, our ability to successfully intervene to prevent or reverse microvascular disease is quite limited. Insights gained by the use of newer tools, including genetic, proteomic, metabolomics, and other analyses, will certainly add new insights in the basic functioning of microvascular cells, and these insights will light the way to improved therapies.