The 2017 Hormone Therapy Position Statement of The North American Menopause Society

The North American Menopause Society 2017 Hormone Therapy Position Statement Advisory Panel

Disclosures

The North American Menopause Society (NAMS). 2018;24(7):728-753. 

In This Article

Lung Cancer

In the WHI, after a median 13 years' cumulative follow-up across intervention and posttrial follow-up, the incidence of lung cancer did not differ significantly between placebo and treatment with either CEE alone or CEE + MPA.[14,256] Post hoc analysis of the WHI intervention phase showed that women randomized to CEE + MPA had more deaths from non-small cell lung cancer compared with placebo, limited to past and current smokers in women aged older than 60 years.[256,257] Five meta-analyses showed consistency of either no association or a significant reduction in the association of lung cancer with HT.[258–262]

Key Points

  • There appears to be an overall neutral effect of HT on lung cancer incidence.

  • Smoking cessation should be encouraged, with increased surveillance for older smokers, including current or past users of HT.

Comments

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