The 2017 Hormone Therapy Position Statement of The North American Menopause Society

The North American Menopause Society 2017 Hormone Therapy Position Statement Advisory Panel

Disclosures

The North American Menopause Society (NAMS). 2018;24(7):728-753. 

In This Article

Joint Pain

Direct binding of estrogen to ERs acts on joint tissues, protecting their biomechanical structure and function and maintaining overall joint health, but the exact effect of estrogen on osteoarthritis remains controversial.[130–132]

Preclinical studies and clinical trials of ET have reported inconsistent results of the effects of estrogen on osteoarthritis and arthralgia, with suggestive evidence that estrogen and SERMs may have benefits.[133]

In the WHI, women on combined CEE + MPA had less joint pain or stiffness compared with those on placebo (47.1% vs 38.4%; OR, 1.43; 95% CI, 1.24–1.64) andmore discomfort when stopping.[134] In the CEE-alone arm, women randomized to CEE had a statistically significant reduction in joint pain frequency after 1 year compared with the placebo group (76.3% vs 79.2%; P = 0.001).[135]

Key Point

  • Women in the WHI and other studies have shown less joint pain or stiffness compared with those on placebo.

Comments

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