Medications That Cause Dry Mouth As an Adverse Effect in Older People

A Systematic Review and Metaanalysis

Edwin C. K. Tan, PhD; Duangjai Lexomboon, PhD; Gunilla Sandborgh-Englund, PhD; Ylva Haasum, PhD; Kristina Johnell, PhD


J Am Geriatr Soc. 2018;66(1):76-84. 

In This Article


Our systematic review found that medication use was significantly associated with xerostomia and salivary gland hypofunction in older individuals. Findings of the metaanalyses show that the risk of xerostomia was greatest for drugs used for urinary incontinence, followed by antidepressants and psycholeptics. Future research should develop a risk score for medication-induced dry mouth to assist with prescribing and medication management.