Four Old Antimicrobials That Still Work Best

Douglas S. Paauw, MD; Joanna M. Pangilinan, PharmD; Laurie Scudder, DNP, NP


January 16, 2018

Old, but Still Good, Antimicrobials

Although attention is often paid to the newest and most expensive blockbuster drugs, let's not forget older agents that have stood the test of time for treatment of a variety of infections. These four antimicrobials should enter the new year with you and your prescription pad.

Images from Dreamstime, Alamy


Isoniazid was first synthesized in 1912, and activity against tuberculosis was identified in 1945. More than 100 years later, and despite growing drug resistance, isoniazid is still a standard component of multidrug treatment regimens for both pulmonary and extrapulmonary disease, although drug susceptibility testing should be performed for previously treated patients.[1]

For more, refer to our Drugs & Diseases discussion of tuberculosis therapy.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.