Multidisciplinary Approach to Cardiac and Pulmonary Vascular Disease Risk Assessment in Liver Transplantation

An Evaluation of the Evidence and Consensus Recommendations

Lisa B. VanWagner; Matthew E. Harinstein; James R. Runo; Christopher Darling; Marina Serper; Shelley Hall; Jon A. Kobashigawa; Laura L. Hammel


American Journal of Transplantation. 2018;18(1):30-42. 

In This Article


A diverse working group representing multiple relevant disciplines (hepatology, transplant surgery, critical care/anesthesiology, and cardiology), from a variety of institutions based on their expertise in this topic, were assembled. The working group initially identified topics relevant to the assessment and management of cardiovascular diseases in LT candidates. Contributors were then assigned 1 key topic to address. Each contributor identified a list of key questions, conducted a systematic literature search, and generated a bibliography of key studies. We then conducted a series of multiple conference calls, whereby contributor findings were presented, debated, and refined. Summary statements on each topic were then developed and presented to the entire group, revising each statement as needed until a final version was agreed upon by all members of the writing group. The document was then independently reviewed by board members of the LICOP, TCC COP, and AST executive board and all comments and revisions were incorporated into the consensus statement.

Each contributor conducted literature searches related to their topic questions via MEDLINE, PubMed, and the bibliographies of all articles that met the search criteria. The quality of the overall evidence and the strength of recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation system (Table S1).[6]