In summary, the combination of dexmedetomidine and ketamine produces definite sedative effects that help children separate quietly from their parents and smoothly accept induction of anesthesia, and is associated with fewer perioperative adverse events. This premedication combination is thus a reasonable option for use in clinical practice.
ANOVA: Analysis of variance; ESS: Emotional State Scale; HR: Heart rate; LMA: laryngeal mask airway
Conduct of the study and publication of the manuscript was supported by the Shanghai Municipal Commission of Health and Family Planning with an award issued to Hui Qiao (Award Number: 20144Y0263).
Availability of data and materials
The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Ethics approval and consent to participate
The trial was approved by the institutional review board of the Eye and ENT Hospital affiliated with Fudan University and registered at the Chinese Clinical Trial Registry with registration number ChiCTR-TRC-14004475. All parents of the included pediatric patients provided written, informed consent.
Consent for publication
Informed consent was obtained and the consent form was signed by the parents of each participant.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Chinese Clinical Trial Register (Unique identifier: ChiCTR-TRC-14004475, Date of registration: 2 April 2014).
BMC Anesthesiol. 2017;17(158) © 2017 BioMed Central, Ltd.