Extracorporeal Photopheresis (Strength of Recommendation D, Level of Evidence 3)
Extracorporeal photopheresis is known to have immunomodulatory effects and has been used in small numbers of patients with pemphigus;[217–222] there are no RCTs. In a recent case series, eight patients with pemphigus were treated with two to six cycles of extracorporeal photopheresis, resulting in complete remission in all but one case. Steroid doses could be tapered in all treated patients.
Extracorporeal photopheresis could be considered in recalcitrant cases of PV where there has been failure to improve with more conventional therapy.
The British Journal of Dermatology. 2017;177(5):1170-1201. © 2017 Blackwell Publishing