New Therapies in Irritable Bowel Syndrome: What Works and When

Orla Craig


Curr Opin Gastroenterol. 2018;34(1):50-56. 

In This Article


Although a specific microbial signature remains elusive, IBS has been associated with qualitative and quantitative changes in the microbiota, a reduction in intestinal microbial diversity appears to be characteristic.[37] This provides a rationale for the use of probiotics in IBS. Probiotics may normalize intestinal dysmotility, enhance intestinal barrier function, reduce circulating levels of pro-inflammatory cytokines and improve visceral hypersensitivity.[38] In a 2014 meta-analysis, probiotics in general were shown to be effective treatments for IBS, they improved global symptoms, abdominal pain, bloating and flatulence.[39] A recommendation, however, of any particular species or strain could not be made.