Vitiligo: An Update on Pathophysiology and Treatment Options

Reinhart Speeckaert; Nanja van Geel


Am J Clin Dermatol. 2017;18(6):733-744. 

In This Article

Associated Disorders

Importantly, non-segmental vitiligo is associated with other autoimmune disorders such as thyroid disease, alopecia areata, psoriasis, diabetes mellitus, rheumatoid arthritis, pernicious anemia, and Addison's disease. Although Addison's disease is still rare in patients with vitiligo (0.3–0.8%), it is far more frequent compared with the general population (0.01%).[12] In a systematic review, autoimmune thyroid disease was found in 14.3% of patients with vitiligo, although prevalence rates vary considerably among studies.[13] A study by our group showed that thyroid disease was most frequent in women (13.4 vs. 5.4%), and vitiligo patients with thyroid disease almost always had lesions on the hands (men 94.4%, women 93.9%). The feet and elbows are also predilection areas for thyroid disease. Other autoimmune disorders were not linked to particular distribution patterns.[14] In patients with segmental vitiligo, no increased rate of autoimmune disorders is observed.