Ceftaroline: An Alternative Broad Spectrum Antibiotic for Pediatric Infections

Marcia L. Buck, PharmD, FCCP, FPPAG, BCPPS

Disclosures

Pediatr Pharm. 2017;23(6) 

In This Article

Dosing Recommendations

The recommended dose of ceftaroline in adults is 600 mg given IV every 12 hours, with duration of 5–14 days for ABSSSI or 5–7 days for CABP. Dosing for pediatric patients is the same for both ABSSSI and CABP. Patients 2 months up to 2 years of age should receive 8 mg/kg every 8 hours, while those 2–18 years of age who weigh 33 kg or less should receive a dose of 12 mg/kg every 8 hours. Children weighing more than 33 kg should receive either 400 mg every 8 hours or the adult dose of 600 mg every 12 hours. The recommended duration of treatment for both ABSSKI and CABP is 5–14 days.[3]

No dosing adjustment is needed in children and adults with mild renal impairment (a creatinine clearance > 50 mL/min/1.73m2 or 50 mL/min). In adults with moderate renal impairment (creatinine clearance 30–50 mL/min), the dose of ceftaroline should be reduced to 400 mg every 12 hours. In patients with severe impairment (creatinine clearance 15–30 mL/min), a dose of 300 mg every 12 hours is recommended. Patients with end-stage renal disease should receive 200 mg ceftaroline every 12 hours. There are no dosing recommendations available for pediatric patients with moderate to severe renal impairment.[3]

Ceftaroline may be infused over 5 to 60 minutes. It may be diluted to a concentration of 4 to 12 mg/mL with normal saline, 5% dextrose, 0.45% sodium chloride, or lactated Ringer's solution. The diluted solution is stable for up to 6 hours at room temperature or 24 hours when refrigerated.[3]

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