Ceftaroline: An Alternative Broad Spectrum Antibiotic for Pediatric Infections

Marcia L. Buck, PharmD, FCCP, FPPAG, BCPPS


Pediatr Pharm. 2017;23(6) 

In This Article

Warnings and Precautions

Ceftaroline is contraindicated in patients with a known sensitivity to it or other cephalosporins. Hypersensitivity reactions, including anaphylaxis, are possible following ceftaroline use. A history of allergic reactions to any beta-lactam antibiotics, including penicillins, cephalosporins, and carbepenems, should be obtained from the patient or family and the risk for cross sensitivity should be considered prior to initiating treatment with ceftaroline.[3]

As with other antibiotics, use of ceftaroline may place the patient at risk for Clostridium difficile-associated diarrhea. Ceftaroline may also produce seroconversion to a positive direct Coombs' test. This has been reported in 11% to 17% of children and adults receiving the drug during phase 3 trials. Any patient developing anemia while receiving ceftaroline should be evaluated for a potential drug-induced hemolytic anemia, and treatment should be discontinued.[1–3]