Delirium and Benzodiazepines Associated With Prolonged ICU Stay in Critically Ill Infants and Young Children

Heidi A. B. Smith, MD, MSCI; Maalobeeka Gangopadhyay, MD; Christina M. Goben, MD; Natalie L. Jacobowski, MD; Mary Hamilton Chestnut, NP; Jennifer L. Thompson, MPH; Rameela Chandrasekhar, PhD; Stacey R. Williams, NP; Katherine Griffith, NP; E. Wesley Ely, MD, MPH; D. Catherine Fuchs, MD; Pratik P. Pandharipande, MD, MSCI


Crit Care Med. 2017;45(9):1427-1435. 

In This Article


In this large prospective cohort study of critically ill infants and young children, delirium and greater benzodiazepine exposures were associated with a lower likelihood of ICU discharge. This is an important finding as delirium occurs in four of 10 critically ill infants and younger children. Hence, interventional trials are necessary to determine whether reducing iatrogenic harm through the optimization of benzodiazepine exposure decreases the burden of pediatric delirium and improves clinical outcomes in children.