With Hepatitis C Virus on the Run, Meet the New Challenge: Hepatocellular Carcinoma

Digestive Disease Week (DDW) 2017

William F. Balistreri, MD


July 26, 2017

HCC: The New Leading Primary Cancer

When considering surveillance for HCC from HCV-related cirrhosis, a clear target group is the cohort of individuals born from 1945 through 1965 ("baby boomers"), who currently constitute approximately 75% of adults with HCV.

Gadiparthi and colleagues[3] evaluated the incidence of HCC, in relation to other primary cancers, in baby boomers in the United States. Using the Surveillance, Epidemiology, and End Results (SEER) 18 registry, they determined the relative incidence of 81 primary cancers from 2003 to 2012.

Within the registry during that entire period, the top five cancers with the highest incidence in the baby boomer cohort included uterine cancer (49%), HCC (48%), prostate cancer (35%), multiple myeloma (31%), and pancreatic cancer (28%). However, by 2012, HCC had surpassed uterine cancer to become the leading primary cancer, with the highest proportion within the baby boomer cohort. Overall, 58% of the liver cancers were diagnosed in patients born from 1945 through 1965. In addition, HCC was associated with the highest percentage of unstaged metastatic disease (12%) compared with other cancers.

With curative treatment options available for patients with HCC, linkage to care and adherence to screening/surveillance guidelines is clearly warranted for early diagnosis of HCC in baby boomers.


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