Radiological Case: Incidental Atypical Sclerosing Papilloma Within a Radial Scar on Digital Breast Tomosynthesis

Susan N. Samreth, MS; Kimberly A. Fitzpatrick, MD; Lauren G. Lebeau, MD; Wendy S. MacKerricher, MD; Marisa H. Borders, MD

Disclosures

Appl Radiol. 2017;46(7):44-47. 

In This Article

Discussion

Radial scars (RS), also known as complex sclerosing lesions (CSL), are benign breast lesions. By convention, RS corresponds to a lesion measuring < 1 cm, while a CSL corresponds to a lesion > 1cm of the same histology.[1] They are often clinically concerning as they share radiographic and histologic features that are very similar to carcinoma. The clinical importance of diagnosing a radial scar is threefold: 1) RS is difficult to distinguish from carcinoma, 2) foci of intraductal or invasive carcinoma can at times be found within or adjacent to a RS, and 3) RS may potentially act as a marker for increased risk for invasive breast cancer or ductal carcinoma in situ.[2]

Mammographic and clinical features that can suggest a diagnosis of RS include an asymmetry or area of architectural distortion (AD) with areas of central translucency, with the absence of a discrete, palpable central mass or skin changes. Classically, RS is described as having a spiculated appearance with a "black star" effect in which the spicules are surrounded by an absence of a solid tumor mass.[2] Recent literature has demonstrated that DBT might offer the advantage of improved detection of AD over 2-D mammography.[3,4] Furthermore, a cancer detection rate of 21% is reported when AD is discovered on DBT. DBT identified AD that would otherwise remain undetected by traditional mammography.[3]

Ultrasound is another potential modality that can augment the effort to differentiate radial scars from carcinomatous findings. It is important to note that there is no one defining sonographic feature that distinguishes RS from stellate carcinomas. In general, RS has the appearance of a focal area of heterogeneous echogenicity, with or without posterior acoustic shadowing, and with an absence of a discernable mass, or of a solid mass with or without an irregular border. Importantly, RS are often more conspicuous on ultrasound than on mammography.[5] On the other hand, MRI findings of RS are typically composed of a stellate lesion without mass effect in precontrast images, and often exhibit benign kinetic behavior with absent or mild contrast uptake on post-contrast imaging.[2]

Histologically, RS is described as a radially symmetric entity consisting of a fibro-elastotic core from which ducts and lobules radiate, and which may contain epithelial tubules (Figure 6). The typical histologic pattern of RS is what results in the frequent mimicry of breast cancer on mammography.[6]

Figure 6.

Photomicrograph from a section of the left breast surgical excisional biopsy demonstrates a stellate architecture and central fibro-elastotic core with entrapped hyperplastic ducts.

A diagnosis of RS was traditionally diagnosed via surgical excisional breast biopsy. This strategy was sub-optimal since many of the findings represented carcinomas that subsequently required a second surgery to completely resect the newly diagnosed malignancy.[7] A diagnosis of RS can now be attained via percutaneous core needle biopsy. However, when a potential cancer is suspected, an accurate diagnosis of RS without malignancy may require more core tissue samples as compared to biopsy of a carcinoma. Core needle biopsy in the setting of adequately sampled RS may eliminate the need for surgical biopsy.[8]

Still, malignancy is often underestimated even in the setting of percutaneous biopsy-proven RS due to sampling and diagnostic error attributed to the difficulty in differentiating RS from carcinoma. Furthermore, mammographic and sonographic findings of RS are not always predictive of malignancy at surgery. As such, it is for the most part still recommended that RS found on percutaneous biopsy be surgically excised in order to definitely exclude the presence of malignancy.[9]

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