Proton Pump Inhibitor-responsive Esophageal Eosinophilia: Still a Valid Diagnosis?

Javier Molina-Infante; Pedro L. Gonzalez-Cordero; Alfredo J. Lucendo

Disclosures

Curr Opin Gastroenterol. 2017;33(4):285-292. 

In This Article

Conclusion

PPI-REE is an inappropriate disease descriptor, arbitrarily based on a response to a single drug, and should be abandoned. Unlike typical GERD patients, patients who have esophageal eosinophilia and esophageal symptoms that resolve with PPI therapy have phenotypic, molecular, mechanistic, and therapeutic features indistinguishable from similar patients who do not respond to PPIs. These patients with PPI responsiveness should be considered within the spectrum of EoE.

Comments

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