Baseline Prevalence of Birth Defects Associated With Congenital Zika Virus Infection — Massachusetts, North Carolina, and Atlanta, Georgia, 2013–2014

Janet D. Cragan, MD; Cara T. Mai, DrPH; Emily E. Petersen, MD; Rebecca F. Liberman, MPH; Nina E. Forestieri, MPH; Alissa C. Stevens, MPH; Augustina Delaney, PhD; April L. Dawson, MPH; Sascha R. Ellington, MSPH; Carrie K. Shapiro-Mendoza, PhD; Julie E. Dunn, PhD; Cathleen A. Higgins; Robert E. Meyer, PhD; Tonya Williams, PhD; Kara N.D. Polen, MPH; Kim Newsome, MPH; Megan Reynolds, MPH; Jennifer Isenburg, MSPH; Suzanne M. Gilboa, PhD; Dana M. Meaney-Delman, MD; Cynthia A. Moore, MD, PhD; Coleen A. Boyle, PhD; Margaret A. Honein, PhD

Disclosures

Morbidity and Mortality Weekly Report. 2017;66(8):219-222. 

In This Article

Discussion

A congenital Zika syndrome phenotype has been described;[7] however, the birth defects observed are not unique to congenital Zika virus infection, and the full range of effects of congenital Zika infection is not known. The data in this report provide a baseline reference for the prevalence of defects observed with congenital Zika virus infection in the pre-Zika years and demonstrate the importance of data on birth defects prevalence in providing a context within which to assess the impact of teratogenic exposures such as Zika virus infection. Recently published data from the USZPR reported 26 infants and fetuses with these same birth defects among 442 completed pregnancies with laboratory evidence of Zika virus infection during a 9-month period in 2016. This proportion (58.8 per 1,000) is approximately 20 times higher than the prevalence (2.86 per 1,000) from the three population-based birth defects surveillance programs during the pre-Zika years. In addition, of the 26 USZPR infants and fetuses, 22 had a brain abnormality or microcephaly.[2] This proportion (49.8 per 1,000; CI = 33.1–74.8) is approximately 33 times higher than the prevalence (1.5 per 1,000) among pregnancies in the pre-Zika years.

A recently published report from New York took a somewhat different approach to establishing a pre-Zika baseline for congenital birth defects. It examined diagnoses of microcephaly, but not other defects, for the period 2013–2015 and found that, before evidence of importation of Zika virus infections, the overall prevalence of microcephaly in New York was 7.4 per 10,000 live births (0.74 per 1,000), and the prevalence of severe congenital microcephaly (newborn head circumference <3rd percentile for sex and gestational age) was 4.2 per 10,000 (0.42 per 1,000).[8]

The findings in this report are subject to at least six limitations. First, population-based surveillance programs strive to ascertain the prevalence of birth defects among all members of a specified population. In contrast, the aim of USZPR is to estimate the proportion of birth defects among pregnancies with laboratory evidence of possible Zika virus infection, a specific subgroup of the general population.[2] This could lead to selection bias with USZPR if, for example, pregnancies with fetal abnormalities detected prenatally were more likely to be tested for Zika virus and reported. Second, birth defects surveillance programs identify diagnoses among infants and fetuses mostly through review of administrative records, often at inpatient facilities. Although these programs use multisource ascertainment, some birth defects could be missed if they were prenatally diagnosed or if infants were delivered at sites outside of the usual ascertainment sources, if infants were evaluated solely in outpatient settings, or if some birth defect diagnoses did not receive an administrative code. In contrast, USZPR receives reports of pregnant women with laboratory evidence of possible Zika virus infection and resulting fetal and infant outcomes. The prospective nature of this ascertainment and direct follow-up of individual reported pregnancies could result in closer scrutiny of the outcomes and more frequent and detailed detection of abnormalities than is typical with population-based birth defects surveillance programs. Third, data from these three birth defects surveillance programs might not be generalizable to the United States. The USZPR-published data included reports from any of the U.S states and the District of Columbia. Also, it is possible that some pregnancies with Zika virus infection were present in the birth defects surveillance populations during the pre-Zika years as a result of travel to areas with Zika virus outside the Americas. Fourth, birth defects surveillance programs traditionally do not ascertain diagnoses from settings where congenital deafness is diagnosed; therefore, these data likely do not include the majority of infants with congenital sensorineural deafness. Fifth, published data from USZPR on the proportion of infants and fetuses with other types of birth defects that are not thought to result from congenital Zika virus infection are not available, making it impossible to assess differences in the frequency of other birth defects. Finally, published data from USZPR include many pregnancies with unspecified flavivirus infections, and thus the estimates of the proportion with birth defects potentially related to Zika virus infection might underestimate the actual Zika impact, given that some included pregnant women likely had other flavivirus infections, increasing the size of the denominator.

The birth defects surveillance data in this report were compiled from a period before introduction of Zika virus in the Americas, using the CDC surveillance case definition of birth defects potentially related to Zika virus infection; this is the same case definition adopted by USZPR. The higher proportion of these defects among pregnancies with laboratory evidence of Zika infection in USZPR supports the relationship between congenital Zika virus infection and these birth defects.[1,2] These data demonstrate the critical contribution of population-based birth defects surveillance to understanding the impact of Zika virus infection during pregnancy. In 2016, CDC provided funding for 45 local, state, and territorial health departments to conduct rapid population-based surveillance for defects potentially related to Zika virus infection, which will provide essential data to monitor the impact of Zika virus infection in the United States.

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