Salivary Cortisol and Cortisone After Low-Dose Corticotropin Stimulation in the Diagnosis of Adrenal Insufficiency

Ingrid Yin Fung Mak; Benjamin Yick Toa Au Yeung; Ying Wai Ng; Cheung Hei Choi; Heidi Yan Ping Iu; Chi Chung Shek; Sau Cheung Tiu


J Endo Soc. 2017;1(2):96-108. 

In This Article


Our study showed that peak salivary cortisol and cortisone performed well in the diagnosis of AI, and better than basal values. The cutoffs generated from the ROC curves were 376, 8.6, and 33.5 nmol/L for peak post-LDSST serum cortisol, salivary cortisol, and salivary cortisone, respectively. Those for basal serum cortisol, salivary cortisol, and salivary cortisone were 170, 1.7, and 12.5 nmol/L, respectively. Although we report the precise values generated by the ROC curves, in clinical applications the analytic and biologic variations of all tests should be taken into account, with rounding off of cutoff values appropriate to the degree of variability.