Diet and Gastroesophageal Reflux Disease: Role in Pathogenesis and Management

Sajiv Sethi; Joel E. Richter


Curr Opin Gastroenterol. 2017;33(2):107-111. 

In This Article

Tobacco and Substance use

Tobacco use is implicated in the exacerbation of reflux symptoms and cessation of use has been associated with reduced reflux symptoms.[7] A large prospective population based cohort study consisting of 29 610 participants demonstrated decreased symptoms of severe reflux in normal weight individuals on medical treatment compared to patients who continued daily tobacco use (OR = 5.67; 95% CI, 1.36–23.64).[23] These findings were not duplicated in obese patients, possibly because of the different pathophysiology of GERD in obesity as compared to tobacco use.[23] Prior literature also showed that the duration of smoking was associated with esophageal dysmotility and emptying.[12] Use of other substances such as hookah smoking and opium use in noncigarette smokers may have a positive correlation with GERD symptoms as well.[24]