Diet and Gastroesophageal Reflux Disease: Role in Pathogenesis and Management

Sajiv Sethi; Joel E. Richter


Curr Opin Gastroenterol. 2017;33(2):107-111. 

In This Article

Current Management

Currently, the predominant pharmacological therapy for GERD is acid suppression, making PPIs among the most widely prescribed medications in the United States for decades. This is largely because of the prevalence of GERD and gastrointestinal bleeding combined with the belief that PPIs have few side effects. However, recent observational literature has demonstrated that PPI therapy is associated with many potential side effects such as increased risk of acute and chronic kidney disease, hypomagnesemia, Clostridium difficile infection, dementia, and osteoporotic fractures.[10] Although further studies are necessary to more clearly elucidate these risks, such alarming data further underscore the importance of nonpharmacologic methods for controlling of GERD.

At this time, the first-line therapy for patients with GERD is dietary modification, which has been endorsed by the National Institutes of Health and the American College of Gastroenterology.[1] However, few studies have embarked upon the task of evaluating the role of diet in GERD. Thus, there exists an overall paucity of data on the role of diet in the pathogenesis and management of the disease. The aim of this article is to review the recent literature on the relationship between gastroesophageal reflux and nutrition and provide a summary of the latest advancements in the field.