Effects of Conjugated Linoleic Acid and Metformin on Insulin Sensitivity in Obese Children

Randomized Clinical Trial

Nayely Garibay-Nieto; Gloria Queipo-García; Flor Alvarez; Mayra Bustos; Erendira Villanueva; Fernando Ramírez; Mireya León; Estibalitz Laresgoiti-Servitje; Ravindranath Duggirala; Teresa Macías; Sergio Cuevas; Abel Jalife; Miguel Fonseca-Sánchez; Fabiola Serratos; Juan Carlos López-Alvarenga


J Clin Endocrinol Metab. 2017;102(1):132-140. 

In This Article


The current study demonstrates the benefits of an LIP and additional effect of CLA over the gold standard EHCT. Lifestyle intervention, independent of any treatment, showed effects on the main outcome variables, specifically weight, height, BMI, waist circumference, surrogate indexes of insulin resistance, and fitness condition, in all of the groups. IRS2 upregulation was evident in CLA-treated patients; this mechanism might be involved in insulin-sensitizing effects on skeletal muscle.

Finally, the incidence of hypertriglyceridemia and hypo-α-lipoproteinemia in CLA-treated patients might be a concern and may be related to the types of CLA isomers used in this study. Further research to evaluate the benefits of different mixtures of CLA isomers may be warranted.