Testicular Growth and Spermatogenesis: New Goals for Pubertal Hormone Replacement in Boys With Hypogonadotropic Hypogonadism?

A Multicentre Prospective Study of hCH/rFSH Treatment Outcomes During Adolescence

Julia Rohayem; Berthold P. Hauffa; Margaret Zacharin; Sabine Kliesch; Michael Zitzmann


Clin Endocrinol. 2017;86(1):75-87. 

In This Article


The availability of hCG and rFSH for replacement of gonadotropins provides an alternative option for endocrinologists to safely induce puberty in boys with hypogonadotropic hypogonadism, leading to normal linear growth and virilization, testicular enlargement and early induction of spermatogenesis. This method is effective and reassuring for affected individuals and is likely to reduce the expense, duration and anxiety of late fertility induction. Favourable outcomes during adolescence appear not to be compromised by short-term prior testosterone substitution. Clinical parameters, reflecting the onset and severity of GnRH and/or gonadotropin deficiency, may serve as tools to predict response to treatment.