Future Risks of Traumatic Brain Injury

Alan R. Jacobs, MD


January 12, 2017

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This is the Medscape Neurology Minute. I'm Dr Alan Jacobs.

Researchers from the Icahn School of Medicine at Mount Sinai and the University of Washington School of Medicine have published a study analyzing the effects of traumatic brain injury (TBI) with loss of consciousness for 1 hour or less on future risk for clinical and neuropathologic evidence of Alzheimer disease, Parkinson disease, and other dementias.[1]

Subject data came from three large prospective cohort studies, including the Religious Orders Study, the Memory and Aging Project, and the Adult Changes in Thought Study.

They included 7130 participants, of which 865 reported a history of TBI with loss of consciousness.

In over 45,000 person-years of follow-up, 1537 cases of dementia and 117 cases of Parkinson disease were identified.

The researchers found no association between TBI with loss of consciousness and incident dementia or Alzheimer disease. However, there was a strong association for TBI with incident Parkinson disease; progression of parkinsonian signs; and Lewy bodies in substantia nigra, locust ceruleus, and frontal or temporal cortex. TBI was also associated with cortical microinfarcts.

The authors concluded that TBI with loss of consciousness is associated with risk for Lewy body accumulation and progression of parkinsonism and Parkinson disease but not for dementia, Alzheimer disease, amyloid plaques, or neurofibrillary tangles.

This has been the Medscape Neurology Minute. I'm Dr. Alan Jacobs.


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