Throughout all phases of wound healing, oxygen plays a substantial role. Its effects vary depending on whether the wound is in a hypoxic, normoxic, or in a hyperoxic state. The following are the key points. First during energy metabolism, oxygen is needed for mitochondrial cytochrome oxidase. This in turn produces high-energy phosphates which then are needed for many cellular functions. Second, in collagen synthesis oxygen is involved in the hydroxylation of proline and lysine into procollagen which leads to collagen maturation. Third, in angiogenesis, hypoxia is required to start the process, but it has been shown that if oxygen is administered it can accelerate and sustain vessel growth. Finally, the antimicrobial action of oxygen occurs when converted by leukocytic NADPH oxidase to a superoxide ion which kills bacteria.
Wounds. 2016;28(8):264-270. © 2016 HMP Communications, LLC