Functional Dyspepsia, 2016

Nicholas J. Talley; Marjorie M. Walker; Gerald Holtmann


Curr Opin Gastroenterol. 2016;32(6):467-473. 

In This Article

Role of Diet

As the majority of patients with functional dyspepsia have PDS, there has been an increasing interest in dietary triggers. Göktas et al.[14] report dietary data on 168 cases with functional dyspepsia and 135 healthy controls; fatty and fried foods as well as spicy foods (but not wheat) were more likely to precipitate symptoms in all subtypes of functional dyspepsia cases. A body of work has implicated fat in meals as precipitating symptoms of dyspepsia. As Feinle-Bisset[15] points out in an excellent review, entry of the meal contents into the duodenum is key; small bowel receptors release hormones such as CCK, which alters gastroduodenal function, including gastric emptying rates, as well as signaling the brain. This suggests a central role for duodenal dysfunction in functional dyspepsia. Carbonated drinks also aggravated PDS, but snacks and meal frequency were not associated with symptoms of functional dyspepsia.[14]

In contrast, an Iranian study reported in a cross-sectional analysis of 4763 adults that more frequent meals were associated with less early satiety, and frequent consumption of snacks appeared protective, although it is likely those who have early satiety avoid large meals and snacks because symptoms are precipitated.[16]