Jessa Baker, BA; Chris Jeziorkowski, MD; Cory Siebe, MD; Megan Boysen Osborn, MD, MHPE

Disclosures

Western J Emerg Med. 2016;17(5):623-626. 

In This Article

Introduction

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a form of autoimmune encephalitis with prominent neuropsychiatric features. Patients present with acute psychosis, memory impairment, dyskinesias, seizures, and/or speech disorders. The clinical course is often complicated by respiratory failure, requiring intubation. Approximately half of patients are found to have an associated ovarian tumor, which expresses NMDAR. Recognition of anti-NMDAR encephalitis by emergency physicians is essential in order to initiate early treatment and avoid psychiatric misdiagnosis. The disease is highly treatable with tumor removal and immunosuppression, and most patients demonstrate a full recovery. In this case series, we report two cases of anti-NMDAR encephalitis in adult women in the United States and provide a review of the literature.

Comments

3090D553-9492-4563-8681-AD288FA52ACE

processing....