Recent Advances in Understanding Renal Ammonia Metabolism and Transport

I. David Weiner; Jill W. Verlander


Curr Opin Nephrol Hypertens. 2016;25(5):436-443. 

In This Article


Ammonia metabolism is critical to acid–base homeostasis for the maintenance of normal health, both under basal conditions and in response to a variety of clinical circumstances. Recent studies have substantially advanced our understanding of ammonia metabolism in a variety of clinically important conditions. Additional studies have advanced understanding of the mechanism of ammonia metabolism by showing critical roles of glutamine synthetase and NBCe1, and by carefully determining the molecular ammonia species transported by Rh glycoproteins.