Impact of Prehospital Care on Outcomes in Sepsis

A Systematic Review

Michael A Smyth, MSc; Samantha J Brace-McDonnell, MSc; Gavin D Perkins, MD


Western J Emerg Med. 2016;17(4):427-437. 

In This Article


There is little robust evidence addressing the impact of prehospital interventions on outcomes in sepsis. That which is available is of very low quality and indicates that prehospital interventions have limited impact on outcomes in sepsis beyond improving process outcomes and expediting the patients passage through the emergency care pathway. Evidence indicating that prehospital antibiotic therapy and fluid resuscitation improve patient outcomes is lacking. Well-conducted studies addressing key clinical interventions, such as antibiotic administration and fluid resuscitation are required.