Impact of Prehospital Care on Outcomes in Sepsis

A Systematic Review

Michael A Smyth, MSc; Samantha J Brace-McDonnell, MSc; Gavin D Perkins, MD


Western J Emerg Med. 2016;17(4):427-437. 

In This Article


We employed a broad search strategy in order to capture as much published literature as possible. Inclusion criteria were similarly not restrictive so as to include as much of the evidence base as possible. To the best of our knowledge, this is the first systematic review addressing the impact of prehospital interventions upon outcomes among sepsis patients. Despite using very broad search criteria, little robust evidence regarding the impact of prehospital care of sepsis patients was identified. The studies found employed disparate methodologies, exhibit significant heterogeneity, generally involve small numbers of patients (limiting the precision of reported results) and were invariably of very low quality. The conclusions that can be drawn from this systematic review are therefore limited and findings should be interpreted with caution.