Effective Chemical Inactivation of Ebola Virus

Elaine Haddock; Friederike Feldmann; Heinz Feldmann


Emerging Infectious Diseases. 2016;22(7):1292-1294. 

In This Article


Our study establishes inactivation procedures for EBOV that can be safely applied to distinct specimen types and research purposes and might also apply to other enveloped, single-strand, negative-sense RNA viruses. Our findings should help to improve and approve SOPs for inactivation without the need for safety testing each individual sample, an unfeasible and unwarranted task in current diagnostic and research operations in high-level biocontainment settings. However, any changes to inactivation SOPs make further safety testing essential. Safety testing for inactivation, at least for EBOV, can rely on cell culture only because this seems to be as sensitive as in vivo testing.