Antibiotic Strategies in the Era of Multidrug Resistance

George Karam; Jean Chastre; Mark H. Wilcox; Jean-Louis Vincent


Crit Care. 2016;20(136) 

In This Article


There is no doubt that we are now faced with greater antibiotic resistance challenges than ever before, limiting treatment options for patients with severe infections. The rate of development of new antimicrobial agents has failed to keep pace with the "ingenuity" of bacteria to mutate and become resistant to antibiotics. We have to adapt to this threat by reducing unnecessary antibiotic prescribing, both qualitatively and quantitatively. We need to optimize control measures to minimize the risk of spread of resistant bacteria, and we have to find novel ways to detect pathogens early. These approaches will help prevent the spread of MDR pathogens and could enable us to direct last-line (and in some cases, narrow-spectrum) antibiotics more effectively to those patients who need them most, rather than the current "broad-spectrum is best" approaches.