Hormonal Changes in Early Androgenetic Alopecia Resemble Those in PCOS

By Reuters Staff

June 23, 2016

NEW YORK (Reuters Health) - Men with early androgenetic alopecia (AGA) have hormonal changes that resemble those in women with polycystic ovarian syndrome (PCOS), suggesting that they may face the same complications.

That's according to a new study in JAMA Dermatology, online June 15. Earlier research has suggested that patterned hair loss in men occurring before age 30 years should be considered the phenotypic equivalent of PCOS.

Dr. Sarita Sanke and colleagues from Lady Hardinge Medical College and Associated Hospitals in New Delhi, India, studied the hormonal profile of 57 men with early androgenetic alopecia compared with 32 age-matched men with no evidence of hair loss.

The average body mass index (BMI) was significantly higher in men with early AGA (22.9 vs. 21.1), the team found. Men with early AGA also had significantly higher mean levels of total testosterone, dehydroepiandrosterone sulfate (DHEAS), luteinizing hormone (LH), and prolactin, along with significantly lower levels of FSH and sex hormone binding globulin (SHBG).

Men with early AGA also had nonsignificantly higher mean insulin levels, and 12 men with AGA (21%) had insulin resistance, compared with three men (9%) in the control group.

"These hormonal parameters more or less resemble the profile of women with PCOS, and we propose that these men can be considered phenotypic equivalents to women with PCOS," the authors conclude.

"These men could be exposed to the same risks as women with PCOS, including metabolic syndrome, insulin resistance, cardiovascular disease, and infertility, which needs to confirmed by large, multicenter studies. Men with early AGA may be exposed to these risks regardless of AGA grade or severity," they add.

Dr. Sanke did not respond to a request for comments.

SOURCE: http://bit.ly/28MSiCJ

JAMA Dermatol 2016.