Lung Cancer in Chronic Obstructive Pulmonary Disease Patients, It Is Not Just the Cigarette Smoke

Pablo Sanchez-Salcedo; Javier J. Zulueta


Curr Opin Pulm Med. 2016;22(4):344-349. 

In This Article


COPD, considering it either by the presence of airflow obstruction or emphysema, has strong ties with lung cancer that go well beyond the fact that both entities share cigarette smoke as the main etiologic factor. Many convincing mechanisms have been proposed to explain this association, but so far no complete and definite explanations have been reached. Perhaps, COPD should not only be seen as an important risk factor for lung cancer, but also as part of the same disease. Specific features found in patients with lung cancer and with airflow obstruction or emphysema, might help understand the mechanisms of lung carcinogenesis and may lead to the development of specific targets for therapy, as well as to different strategies for the general management of lung cancer.