Severe Sepsis and Septic Shock Associated With Chikungunya Virus Infection, Guadeloupe, 2014

Amélie Rollé; Kinda Schepers; Sylvie Cassadou; Elodie Curlier; Benjamin Madeux; Cécile Hermann-Storck; Isabelle Fabre; Isabelle Lamaury; Benoit Tressières; Guillaume Thiery; Bruno Hoen


Emerging Infectious Diseases. 2016;22(5):891-894. 

In This Article

Abstract and Introduction


During a 2014 outbreak, 450 patients with confirmed chikungunya virus infection were admitted to the University Hospital of Pointe-à-Pitre, Guadeloupe. Of these, 110 were nonpregnant adults; 42 had severe disease, and of those, 25 had severe sepsis or septic shock and 12 died. Severe sepsis may be a rare complication of chikungunya virus infection.


In November 2013, the first autochthonous cases of chikungunya virus (CHIKV) infection were identified in the territory of Saint-Martin in the French West Indies.[1] Since that time, local transmission of the virus has been identified in nearly all Caribbean islands and in Central and South America.[2] In Guadeloupe, an outbreak started in the first weeks of 2014 and ended by November 2014. No new definite case of chikungunya has been reported since January 2015. During the 2014 outbreak, ≈40% of the population (≈160,000 persons) became infected with CHIKV. However, the hospitalization rate for chikungunya was <0.5%. A total of 450 patients with CHIKV infection and a positive reverse transcription PCR (RT-PCR) test result for CHIKV were admitted to the University Hospital of Pointe-à-Pitre (UHPAP), Guadeloupe, and were hospitalized >24 hours. Of these 450 patients, 241 were children, 99 were pregnant women, and 110 were nonpregnant adults. The objectives of our study were 1) to describe the characteristics of nonpregnant adult patients who had atypical or severe forms of the disease and 2) to search for predictive factors for severe forms.