Interim Guidance for Interpretation of Zika Virus Antibody Test Results

Ingrid B. Rabe, MBChB; J. Erin Staples, MD, PhD; Julie Villanueva, PhD; Kimberly B. Hummel, PhD; Jeffrey A. Johnson, PhD; Laura Rose, MTS; Susan Hills, MBBS; Annemarie Wasley, ScD; Marc Fischer, MD; Ann M. Powers, PhD


Morbidity and Mortality Weekly Report. 2016;65(21) 

In This Article

Management of Persons With Suspected Zika or Dengue Virus Infection

All patients with clinically suspected dengue virus infection should receive appropriate management to reduce the risk for hemorrhagic complications.[11] Symptomatic and asymptomatic pregnant women with serologic or molecular evidence of recent Zika virus infection should be evaluated and managed for possible adverse pregnancy outcomes and reported to the U.S. Zika Pregnancy Registry or the Puerto Rico Zika Active Pregnancy Surveillance System.[9,10] Among persons for whom serologic testing is unable to determine the most recent infecting flavivirus, an epidemiologic link to a laboratory-confirmed case of dengue or Zika virus disease can be considered in determining the most likely infecting virus.[22] In addition, data on the epidemiology of viruses known to be circulating at the location of exposure and clinical features of these viral infections should be considered. If serologic testing is inconclusive or there is evidence of recent infection with either Zika or dengue virus, patients should be clinically managed for both infections because they might have been infected with either virus. Health care providers with questions about test result interpretation should consult with state or local public health authorities for assistance.