Three-dimensional Ultrasonography and Power Doppler for Discrimination Between Benign and Malignant Endometrium in Premenopausal Women With Abnormal Uterine Bleeding

Mohamed El-Sharkawy; Akmal El-Mazny; Wafaa Ramadan; Dina Hatem; Aly Abdel-Hafiz; Mohamed Hammam; Adel Nada


BMC Womens Health. 2016;16(18) 

In This Article


Endometrial carcinoma is the most common form of gynecologic cancer in developed countries, and it is the fourth most common malignant tumor among women worldwide.[1] Abnormal uterine bleeding is usually the first symptom; therefore, appropriate evaluation of women with premenopausal or postmenopausal bleeding will allow for early diagnosis of endometrial carcinoma and the best opportunity for cure.[2]

Ultrasonography has been extensively used in women suspected of having a gynecological malignancy, especially in ovarian[3] and endometrial[4] cancer. In fact, transvaginal ultrasonography is considered the initial imaging procedure for evaluating abnormal vaginal bleeding due to its ability to depict endometrial pathology, its widespread availability, and its excellent safety profile and cost effectiveness.[5]

Three-dimensional ultrasonography is a new imaging technique that has become currently available in gynecologic practice,[6] specifically in gynecologic oncology.[7] In addition, 3D power-Doppler ultrasonography allows a 3D reconstruction of the vascular network and also calculating vascular indices based on the total and relative amount of power Doppler information within the volume of interest.[8]

The aim of this study is to evaluate the efficacy of 3D ultrasonography and power Doppler for discrimination between benign and malignant endometrium in premenopausal women with abnormal uterine bleeding.