Mammographic Breast Density in Infertile and Parous Women

Meggiorini Maria Letizia; Vestri Anna Rita; De Stefano Maria Grazia; Cipolla Valentina; Bellati Filippo; Maffucci Diana; Nusiner Maria Paola; Aragona Cesare; De Felice Carlo

Disclosures

BMC Womens Health. 2016;16(8) 

In This Article

Results

Mean age of the 151 case group patients was 38.96 ± 2.88 and mean BMI was 23.15 ± 3.88. All were affected by primary infertility: 57.8 % sine causa, 37 % ovulatory factors and 5.2 % endometriosis. Of this group, 6.6 % had a positive family history of breast cancer and 40.4 % had received hormonal contraceptive therapy (HCT). Mean age at menarche was 12.34 ± 1.49.

Mean age of the 154 control group patients was 41.79 ± 3.09 and mean BMI was 22.58 ± 3.05. Of this group 52 % had a positive family history of breast cancer and 44.2 % had received contraceptive therapy. Mean age at menarche was 12.44 ± 1.47.

The mean age difference between the two groups was statistically significant, but difference in BMI values was not statistically significant (Table 1).

All mammograms included in the study were classified as P (perfect) or G (good) according to the PGMI evaluation system.

Evaluation of mammographic features showed that 33.1 % (50/151) of case group patients and 46.1 % (71/154) of control group patients were classified BIRADS-1/BIRADS-2; p < 0.05, and that 66.9 % (101/151) of case group patients and 53.9 % (83/154) of control group patients were classified BIRADS-3/BIRADS-4; p < 0.05 (Table 2). Adjusted OR for the case group vs. the control group in categories BIRADS-3/BIRADS-4 was 1.78 (95 % CI: 1.10–2.89); p = 0.02 (Table 3).

Boyd classification of mammographic features showed that 19.2 % (29/151) of case group patients and 22.7 % (35/154) of control group patients were assigned to categories A and B (p > 0.05); 27.2 % (41/151) of case group patients and 45.5 % (70/154) of control group patients were assigned to categories C and D (p < 0.05); 53.6 % (81/151) of case group patients and 31.8 % (49/154) of control group patients were assigned to categories E and F; (p < 0.05) (Table 2).

Adjusted OR for the case group vs. the control group in Boyd categories E and F was 2.05 (95 % CI: 1.07–3.93) (p = 0.03). Adjusted OR for categories C and D vs. categories A and B was 0.75 (95 % CI:0.39–1.46) (p = 0.39) (Table 4).

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