The Impact of Long-term School-based Physical Activity Interventions on Body Mass Index of Primary School Children

A Meta-analysis of Randomized Controlled Trials

Hong Mei; Yuelin Xiong; Shuixian Xie; Siyu Guo; Yukun Li; Bingbing Guo; Jianduan Zhang

Disclosures

BMC Public Health. 2016;16(205) 

In This Article

Methods

Literature Search

Keywords in English, including physical activity, physical education, exercise or active break, body mass index or BMI or obesity, and school children were used individually or in combination to retrieve related articles published between January 1990 and March 2015 from major databases (PubMed, Web of Science, the Cochrane Library and Google Scholar). The retrieve protocol was like ((((physical activity [MeSH Major Topic]) OR physical education [MeSH Major Topic]) OR exercise [MeSH Major Topic]) AND body mass index [MeSH Major Topic]). The bibliographies of relevant meta-analysis and systematic reviews were also manually investigated to retrieve additional relevant original articles that met the inclusion criteria indicated as follow. The preliminary retrieved references were carefully examined to avoid duplications and omissions.

Inclusion Criteria

The analysis was limited to the studies published in English and with human subjects. The following criteria were used for paper selection: 1) primary school-aged children (6 to 12 year-old) regardless of their weight status, 2) RCT designed, 3) intervention conducted in the school setting, 4) PA intervention duration ≥12 months, 5) available data on the mean and standard deviation (SD) of BMI or the BMI changes from baseline to the final follow-up in both intervention and control groups.

Data Extraction and Validity Assessment

The initial screening of titles and abstracts was performed by one investigator with a randomly selected 10 % of the sample checked by a second investigator. Data were independently extracted by one investigator using a self-made data-collection form developed based on the inclusion criteria and was independently checked by a second investigator. The following information of studies including basic information (authors, publishing year, and study area), study design and sample size, grade and gender of students, intervention type and duration, and PA measurement were extracted from the eligible studies. Another two investigators conducted internal and overall validity assessments independently using the Jadad Scale scoring algorithm.[35] The sum of the scores of all five items forms the final Jadad Scale score (JSS) for each study, ranged from 0 to 5. Studies with JSS equal to or greater than 3 were considered as high quality studies. If the score for the same item differed between the two investigators, a third investigator had to reassess the study and at last come to an agreement on all the items of the included studies. The JSS has been used in previous RCT studies.[36]

Data Synthesis and Analysis

The eligible studies were originated in European, Asian, and African countries and in the United States. The study's design was RCT or cluster RCT with randomization at the school level. The intervention type was stratified as physical activity only (PA) and physical activity plus nutrition (PA&N). Intervention duration was presented in months as a dichotomous variable (12 ~ 24 months and >24 months). PA level was electronically monitored and/or collected by using questionnaires, therefore the measurement was classified as electronic instrument only (I), questionnaire only (Q) or both (I & Q). PA contents detailed the frequency and duration of weekly PA at school. Weekly PA intervention time was calculated as the original physical education time plus the additional PA intervention time, presented as minutes per week (min/week) and was classified as ≤100 min/week and >100 min/week. The final BMI was measured immediately after the completion of the intervention. The Chi-square test was used to compare the difference of JSS between RCT studies and cluster RCT studies.

The primary analysis was focused on the long-term effect of PA interventions on the BMI of primary school children. The mean change in BMI (ΔBMI) for both intervention groups (IG) and control groups (CG) was calculated as BMI at final follow up minus BMI at baseline. For each study, the effect size was the difference in ΔBMI between control and intervention groups (ΔBMIIG-ΔBMICG) and then was expressed as the standardized mean difference (SMD) with a 90 % confidence interval (CI). A crude forest plot was conducted to graph the effect size of studies on ΔBMI using random effect model. In the forest plot, the SMD of each study was displayed, along with a combined estimated variance of the overall effect. I 2 was used to assess the heterogeneity of SMD across the included studies, while Begg's funnel plotting was adopted to visualize the publication bias. Thereafter, one-way sensitivity analysis was performed to assess the robustness of the results by removing each study individually and assessing the I 2 impact on the summary estimate. After removing the studies that highly impact the summary estimate, stratified analyses were used to detect the contribution of study design, origination area, duration, intervention type, PA measurement method, and weekly PA intervention time on the origin of heterogeneity.

All statistical analyses were performed using STATA version 12.0.

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