Concurrent and Clonally Related Pediatric Follicular Lymphoma and Burkitt Lymphoma in a 5-year-old Boy

Aaron C. Shaver, MD, PhD; David Zimmerman, MD; Mingya Liu, MS; Cindy Vnencak-Jones, PhD; Annette S. Kim, MD, PhD


Lab Med. 2016;47(1):43-47. 

In This Article


Pediatric follicular lymphoma shares morphologic similarities with the adult form of the disease but lacks other classic features of adult lymphoma, including t(14;18) translocation, BCL2 overexpression, and transformation to aggressive higher-grade lymphoma. Herein, we report a novel case in which a 5-year-old boy (ethnicity unknown) had follicular lymphoma, along with concurrent high-grade and clonally related disease that fulfilled all of the morphologic, immunophenotypic, and genetic criteria for Burkitt lymphoma, including a t(8;14) translocation involving the MYC gene. To our knowledge, this case is the first reported instance of transformation of follicular lymphoma of any sort into true Burkitt lymphoma and the first reported instance of acquisition of MYC abnormalities in pediatric follicular lymphoma.