The recent literature on hyponatremia has confirmed the importance of the slow correction of severe chronic hyponatremia to prevent ODS and rapid correction of acute hyponatremia to ameliorate cerebral edema, and it has yielded strategies to achieve these goals. The deleterious effects of chronic mild hyponatremia on bone and neurologic function are being increasingly recognized, as well as osmotic and nonosmotic cellular effects of hyponatremia on bone, brain, and other tissues.
Curr Opin Nephrol Hypertens. 2016;25(2):114-119. © 2016 Lippincott Williams & Wilkins