Paraproteinemic Neuropathy: A Practical Review

Richard A. Rison; Said R. Beydoun


BMC Neurol. 2016;16(13) 

In This Article


Individual paraproteinemic disorders exhibit distinct neuropathic phenotypes, often with characteristic, identifiable clinical features. Frequently, prognoses are not well-defined, and in many cases, unknown. Testing should include a general and detailed neurological exam to characterize phenotype, and may include various diagnostic tests depending on the case. PPN treatment often calls for collaboration among several specialties, including hematology, neurology, radiation oncology, surgery, and physical/occupational/recreational/speech/rehabilitation therapy. Treatments for PPN often involve chemotherapy agents that may significantly impact a patient's lifestyle. For these individuals and their families, psychological support is often needed.