Intralymphatic Immunotherapy of Pollen-Induced Rhinoconjunctivitis

A Double-Blind Placebo-Controlled Trial

Terese Hylander; Olivia Larsson; Ulla Petersson-Westin; Mia Eriksson; Susanna Kumlien Georén; Ola Winqvist; Lars-Olaf Cardell


Respiratory Research. 2016;17(10) 

In This Article


This double-blind placebo-controlled trial adds to the existing literature and provides further evidence that ILIT is a safe and effective treatment for pollen-induced allergic rhinitis. ILIT circumvents the drawbacks typically associated with SCIT, namely the frequent injections, high risk for adverse events and long duration of treatment, and may therefore represent a novel lower-cost form of AIT. However, larger and longer-term studies, investigating efficacy as well as immunological mechanisms are required to optimise the ILIT treatment regimes. Nonetheless, the present study lends further support for ILIT being a future safe and effective form of AIT. In addition, the data presented suggests that NPT and high affinity allergen-specific IgG4 may be valuable predictors for the efficacy of ILIT. If so, this represents a simple way to evaluate the long-term persistence of symptom-reducing effects of ILIT.