Mal de Meleda: A Focused Review

Caroline Perez; Amor Khachemoune

Disclosures

Am J Clin Dermatol. 2016;17(1):63-70. 

In This Article

Histology

Histologically, skin biopsy in Mal de Meleda generally shows the expected pattern of hyperkeratosis and acanthosis in the epidermis, without evidence of epidermolysis. Some samples exhibit parakeratosis, while others show orthokeratosis.[29] There is also variation with respect to findings in the stratum granulosum, as both hypergranulosis and normogranulosis have been recorded.[6,30,31] Further, there is histologic involvement beyond the epidermis into the upper dermis with a perivascular lymphocytic dermal infiltrate.[30–32]

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