British Association of Dermatologists and British Photodermatology Group Guidelines for the Safe and Effective Use of Psoralen–Ultraviolet A Therapy 2015

T.C. Ling; T.H. Clayton; J. Crawley; L.S. Exton; V. Goulden; S. Ibbotson; K. McKenna; M.F. Mohd Mustapa; L.E. Rhodes; R. Sarkany; R.S. Dawe

Disclosures

The British Journal of Dermatology. 2016;174(1):24-55. 

In This Article

Oral and Topical Psoralen–Ultraviolet A: The Different Forms Available

There are many different forms of PUVA. Different psoralens are available [8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), trimethylpsoralen (TMP)] and other similar furocoumarin compounds (e.g. khellin) are also used in some areas. The psoralens may be applied topically [as soaks – whole-body, except head and neck, in a bathwater psoralen liquid (bath PUVA); as cream; as gel; as lotion] and by mouth (using different formulations, including microcrystalline tablets and liquid in capsules). Also, different ultraviolet A (UVA) sources are used, including fluorescent BB-UVA lamps, metal halide BB-UVA lamps and sunlight. In the U.K., oral PUVA typically involves administration of microcrystalline tablet 8-MOP dosed according to estimated body surface area followed 2 h later by exposure to fluorescent BB-UVA lamps.[8] Usually, oral 5-MOP (which is more costly and has been less studied) is used if excessive nausea occurs with oral 8-MOP.

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