Combined Intervention With Pioglitazone and n-3 Fatty Acids in Metformin-treated Type 2 Diabetic Patients

Improvement of Lipid Metabolism

Jiri Veleba; Jan Kopecky Jr.; Petra Janovska; Ondrej Kuda; Olga Horakova; Hana Malinska; Ludmila Kazdova; Olena Oliyarnyk; Vojtech Skop; Jaroslava Trnovska; Milan Hajek; Antonin Skoch; Pavel Flachs; Kristina Bardova; Martin Rossmeisl; Josune Olza; Gabriela Salim de Castro; Philip C. Calder; Alzbeta Gardlo; Eva Fiserova; Jørgen Jensen; Morten Bryhn; Jan Kopecky Sr.; Terezie Pelikanova


Nutr Metab. 2015;12(52) 

In This Article


In overweight/obese T2D patients on stable metformin therapy, and in spite of the modest negative effect of Omega-3 on glycemic control and postprandial glucose metabolism, no adverse effect on insulin sensitivity was observed. In response to the combined intervention using Pio& Omega-3, the negative effect of Omega-3 on glucose metabolism was avoided, insulin sensitivity increased, and lipid metabolism was additively improved. Thus, typical T2D patients may be advised to increase their EPA + DHA intake, either in the form of dietary supplements or sea food and fish, in order to increase the efficacy of pharmacotherapies and to prevent diseases linked to inflammation as well as cardiovascular disease, providing that glycemic control is closely monitored. EPA + DHA are likely to bring benefits on cardiovascular health of diabetic patients.