Loss of Histone H3 Lysine 36 Trimethylation Is Associated With an Increased Risk of Renal Cell Carcinoma-specific Death

Thai H Ho; Payal Kapur; Richard W Joseph; Daniel J Serie; Jeanette E Eckel-Passow; Pan Tong; Jing Wang; Erik P Castle; Melissa L Stanton; John C Cheville; Eric Jonasch; James Brugarolas; Alexander S Parker


Mod Pathol. 2016;29(1):34-42. 

In This Article


In this study, we provide the first evidence that loss of H3K36me3 expression is associated with a higher risk of renal cell carcinoma-specific death and progression after nephrectomy for clinically localized clear cell renal cell carcinoma; this association remains significant after adjusting for age and SSIGN score. More importantly, the association remains apparent in the subset of patients with low-risk disease based on the Mayo SSIGN score, thus underscoring the potential for this biomarker to provide clinical utility to urologists. Indeed, if our results are confirmed in future studies, evaluation of H3K36me3 expression could be used alone or in combination with other biomarkers to improve risk stratification and clinical management of the growing number of patients presenting with low-risk clear cell renal cell carcinoma.