Endocrine Care of Transpeople Part II

A Review of Cross-sex Hormonal Treatments, Outcomes and Adverse Effects in Transwomen

Maria Cristina Meriggiola; Giulia Gava


Clin Endocrinol. 2015;83(5):607-615. 

In This Article

Reproductive Function

Prolonged exposure to oestrogens has been associated with decreased spermatogenesis and azoospermia due to gonadotropin suppression,[36–38] but whether long-term testicular damage occurs is unclear. Currently, there are no data in the literature regarding the recovery of spermatogenesis and fertility after discontinuation of CHT.[9] When hormonal therapy is commenced after puberty, long-term cryopreservation and storage of sperm could be offered for future use with assisted reproductive techniques.[39]