Early Respiratory Infections and the Development of Asthma in the First 27 Years of Life

Aino K. Rantala; Maritta S. Jaakkola; Elina M. S. Mäkikyrö; Timo T. Hugg; Jouni J. K. Jaakkola


Am J Epidemiol. 2015;182(7):615-623. 

In This Article


The present results provide new evidence that both URTIs and LRTIs in early life actually predict development of asthma through childhood to young adulthood. These results suggest that preventing respiratory infections in childhood could reduce the development of asthma in childhood as well as in adulthood. These findings also provide evidence to refute the original hygiene hypothesis, according to which early respiratory infections would protect against allergic diseases.